Reactome | Collagen type XI degradation by MMP1,2,3,9

Collagen type XI degradation by MMP1,2,3,9

Stable Identifier

R-NUL-2484859

Type

Reaction [transition]

Species

Bos taurus

Compartment

extracellular region

ReviewStatus

5/5

General

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Collagen type XI degradation by MMP1,2,3,9

Collagen type XI has 3 alpha chain types. The alpha1(XI) and alpha2(XI) chains are distinct gene products unique to collagen XI, while alpha3(XI) is a hyperglycosylated form of the alpha1 chain for collagen II (Burgeson & Hollister 1979, Morris & Bächinger 1987). Collagen type XI is a fibril-forming collagen found in conjunction with collagens type II and IX in cartilage fibrils (Miller & Gay 1987, Mendler et al. 1989). It is thought to be the structural equivalent of collagen V in connective tissue collagen fibrils. The formation of cartilage collagen fibrils requires collagen XI, suggesting a regulatory function (Li et al. 1995, Wu and Eyre 1995).

Mutaions in COL11A1 result in fibrochondrogenesis, a severe, autosomal-recessive, short-limbed skeletal dysplasia (Tompson et al. 2010). Variations in COL11A1, COL11A2 and COL2A1 are associated with the inherited chondrodysplasias Marshall and Stickler syndromes (Annunen et al. 1999).

Collagen type XI is degraded by MMP1 (Eyre et al. 1984), MMP2 (Yu et al. 1990, Smith et al. 1991, Brown et al. 1996), MMP3 (Wu et al. 1991) and MMP9 (Hirose et al. 1992, Pormotabbed et al. 1994).

Literature References

PubMed ID	Title	Journal	Year
6322761	All three chains of 1 alpha 2 alpha 3 alpha collagen from hyaline cartilage resist human collagenase Eyre, DR, Wu, JJ, Woolley, DE	Biochem Biophys Res Commun	1984
2173606	Type XI collagen-degrading activity in human osteoarthritic cartilage Yu LP, Jr, Smith GN, Jr, Brandt, KD, Capello, W	Arthritis Rheum	1990
8305481	Characteristics of 92 kDa type IV collagenase/gelatinase produced by granulocytic leukemia cells: structure, expression of cDNA in E. coli and enzymic properties Pourmotabbed, T, Solomon, TL, Hasty, KA, Mainardi, CL	Biochim Biophys Acta	1994
2005102	Sites of stromelysin cleavage in collagen types II, IX, X, and XI of cartilage Wu, JJ, Lark, MW, Chun, LE, Eyre, DR	J Biol Chem	1991