Reactome | Collagen type X degradation by MMP3, 13

Collagen type X degradation by MMP3, 13

Stable Identifier

R-NUL-2484854

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

General

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SVG | | PPTX | SBGN

Collagen X forms extended hexagonal networks (Kwan et al. 1991, Jacenko et al. 2001). It's distribution is limited to regions of hypertrophic cartilage destined for degradation during endochondral ossification (Schmid & Conrad 1982). It is also found in areas of surface fibrillation and osteophyte formation during the development of osteoarthritic lesions in articular cartilage (von der Mark et al. 1992). In Timp3 knockout mice type X collagen was observed mostly in areas of articular cartilage that stained strongly for collagen cleavage products, suggesting that deposition of type X collagen might be a damage repair mechanism (Sahebjam et al. 2007). Mutations in the gene COL10A1 are associated with Schmid/Japanese type metaphyseal chondrodysplasia (SMCD) (Warman et al. 1993, Ho et al. 2007, Woelfle et al. 2011).

Type X collagen is degraded by MMP1 (Schmid et al. 1986, Welgus et al. 1990, Cole et al. 1993), MMP2 (Cole et al. 1993, Welgus et al. 1990), MMP3 (Wu et al. 1991), MMP13 (Knauper et al. 1997) and ELANE (neutrophil elastase - Kittelberger et al. 1992).

Literature References

PubMed ID	Title	Journal	Year
2005102	Sites of stromelysin cleavage in collagen types II, IX, X, and XI of cartilage Lark, MW, Chun, LE, Eyre, DR, Wu, JJ	J Biol Chem	1991
9065415	The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction O'Shea, M, Cowell, S, Morris, H, Smith, B, Zardi, L, López-Otin, C, Knäuper, V, Murphy, G	J Biol Chem	1997