Collagen type IX degradation

Stable Identifier
R-NUL-2482219
Type
Reaction [transition]
Species
Bos taurus
Compartment
General
SVG |   | PPTX  | SBGN
Collagen type IX degradation

Type IX collagen is heterotrimeric, interacting covalently with type II collagen fibril surfaces, suggesting that they represent macromolecular bridges between fibrils and other cartilage matrix components (Eyre et al. 1987, Olsen 1997). Degradation of type IX (and type II) collagen is seen at the onset of inflammatory arthritis (Kojima et al. 2001).

Collagen type IX is cleaved by MMP3 (Okada et al. 1989, Eyre et al. 1991, Wu et al. 1991) and MMP13 (Knauper et al. 1997).

Literature References
PubMed ID Title Journal Year
9065415 The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction

Knäuper, V, Cowell, S, Smith, B, López-Otin, C, O'Shea, M, Morris, H, Zardi, L, Murphy, G

J Biol Chem 1997
2005102 Sites of stromelysin cleavage in collagen types II, IX, X, and XI of cartilage

Wu, JJ, Lark, MW, Chun, LE, Eyre, DR

J Biol Chem 1991
Participants
Catalyst Activity

metalloendopeptidase activity of MMP3,13 [extracellular region]

Orthologous Events
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