Cleavage of collagen type VIII by ELANE

Stable Identifier
R-NUL-2482182
Type
Reaction [transition]
Species
Homo sapiens
Compartment
General
SVG |   | PPTX  | SBGN
Cleavage of collagen type VIII by ELANE

Collagen type VIII is a short chain, network-forming collagen,thought to play a role in tissue remodeling and repair (Shuttleworth 1997, Weitkamp et al. 1999). There are two alpha chain subtypes, found in a ratio of two alpha-1 to one alpha-2 chains (Mann et al. 1990) in the typical collagen heterotrimer. Studies suggest that type VIII collagen is a major component of the hexagonal lattice seen in Descemet's membrane (Mann et al. 1990). Mutations in both alpha chains have been associated with Fuchs endothelial corneal dystrophy (FECD), a degenerative disease of the corneal endothelium (Jun et al. 2012). Collagen type VIII can be degraded by neutrophil elastase (ELANE, ELA2; Kittelberger et al. 1992).

Literature References
PubMed ID Title Journal Year
1515454 Cleavage of type VIII collagen by human neutrophil elastase

Kittelberger, R, Neale, TJ, Francky, KT, Greenhill, NS, Gibson, GJ

Biochim Biophys Acta 1992
Participants
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of ELANE [extracellular region]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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