Dystroglycan binds Agrn and Hspg2

Stable Identifier
R-NUL-2426638
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane, extracellular region
Synonyms
Dystroglycan binds agrin and perlecan
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Dystroglycan binds Agrn and Hspg2
Alpha-dystroglycan binds G domain-like sequences in other extracellular matrix molecules such as agrin (Gee et al. 1994, Campanelli et al. 1994, Sugiyama et al. 1994, Yamada et al. 1996, Gesemann et al. 1996) and perlecan (Peng et al. 1998, Talts et al. 1999). DG knockout mice exhibit severe disruption of basement membranes and embryonic stem cells fail to deposit laminin, suggesting a role for DG in laminin matrix formation (Henry & Campbell 1998). Conditional ablation of DG expression in cultured mammary epithelial cells disrupted laminin-111-induced polarity and beta-casein production, and abolished laminin binding and assembly on the cell surface. Dystroglycan re-expression restored these deficiencies (Weir et al. 2006).
Literature References
PubMed ID Title Journal Year
10022829 Binding of the G domains of laminin alpha1 and alpha2 chains and perlecan to heparin, sulfatides, alpha-dystroglycan and several extracellular matrix proteins

Brancaccio, A, Timpl, R, Talts, JF, Göhring, W, Andac, Z

EMBO J. 1999
8043271 Dystroglycan binds nerve and muscle agrin

Hall, ZW, Sugiyama, J, Bowen, DC

Neuron 1994
Participants
Input
Output
Orthologous Events
Dystroglycan binds AGRN and HSPG2 (Homo sapiens)
Authored
Jupe, S  (2012-11-30)
Reviewed
Ricard-Blum, S  (2013-05-22)
Created
Jupe, S  (2012-08-08)
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