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TGFBR2 phosphorylates Pard6a
Stable Identifier
R-NUL-2161165
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cell junction
,
cytosol
,
extracellular region
,
plasma membrane
ReviewStatus
5/5
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
TGFBR2, recruited to tight junctions, phosphorylates mouse FLAG-tagged Pard6a exogenously expressed in human embryonic kidney cell line, HEK293 (Ozdamar et al. 2005).
Literature References
PubMed ID
Title
Journal
Year
15761148
Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity
Barrios-Rodiles, M
,
Zhang, Y
,
Wrana, JL
,
Wang, HR
,
Bose, R
,
Ozdamar, B
Science
2005
Participants
Input
x 13
ATP [cytosol]
Tight Junction Complex:TGFB1:TGFBR2:TGFBR1:Pard6a:RHOA [cell junction]
(Homo sapiens)
Output
x 13
ADP [cytosol]
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-Pard6a:RHOA [cell junction]
(Homo sapiens)
Orthologous Events
TGFBR2 phosphorylates TGFBR1 and PARD6A (Homo sapiens)
Authored
Orlic-Milacic, M (2012-04-05)
Reviewed
Huang, T (2012-05-14)
Created
Orlic-Milacic, M (2012-03-09)
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