Ubiquitination of PAK-2p34

Stable Identifier
R-NUL-212920
Type
Reaction [omitted]
Species
Oryctolagus cuniculus
Compartment
General
SVG |   | PPTX  | SBGN
Ubiquitination of PAK-2p34

PAK-2p34 is ubiquitinated prior to degradation (Jakobi et al., 2003). Here, ubiquitination of PAK-2p34 is described as occurring in the cytosol. However, to date it is not known whether this occurs in the nucleus or in the cytoplasm. Evidence for this reaction comes from experiments using both human and rabbit proteins. The polyubiquitin synthesized in the reaction is inferred to contain lysine-48 (K48) linkages because the modified protein is targeted to the proteasome (Komander 2009).

Literature References
PubMed ID Title Journal Year
12853446 Caspase-activated PAK-2 is regulated by subcellular targeting and proteasomal degradation

Jakobi, R, McCarthy, CC, Koeppel, MA, Stringer, DK

J Biol Chem 2003
Participants
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of Ubiquitin ligase [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created