Proteasome mediated degradation of PAK-2p34

Stable Identifier
R-NUL-212917
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
General
SVG |   | PPTX  | SBGN
Proteasome mediated degradation of PAK-2p34

Proteolytically activated PAK-2p34, but not full-length PAK-2, is degraded rapidly by the proteasome (Jakobi et al., 2003). Here, degradation of PAK-2p34 is described as occurring in the cytosol. However, to date it is not known whether this occurs in the nucleus or in the cytoplasm.

Literature References
PubMed ID Title Journal Year
12853446 Caspase-activated PAK-2 is regulated by subcellular targeting and proteasomal degradation

Jakobi, R, McCarthy, CC, Koeppel, MA, Stringer, DK

J Biol Chem 2003
Participants
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created