Peptide loading on MHC class I in phagosome

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Peptide loading on MHC class I in phagosome

Peptides translocated back into the phagosomal lumen are loaded onto MHC class I molecules. Guermonprez et al. (2003) detected the components of the peptide loading complex (TAP, tapasin, calreticulin and ERp57) together with MHC class I in purified early phagosomes. They observed peptide loading in the presence of ATP in purified phagosomes expressing HLA-A2, incubated with iodinated S-9-L peptide. From these experiments they concluded that TAP-imported peptides can be loaded on MHC class I molecules in the lumen of phagosomes. Houde et al. (2003) also observed OVA peptide SIINFEKL:MHC-I complex in the phagosome lumen.

Literature References
PubMed ID Title Journal Year
14508489 ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells

Guermonprez, P, Saveanu, L, Kleijmeer, M, Davoust, J, Van Endert, P, Amigorena, S

Nature 2003
14508490 Phagosomes are competent organelles for antigen cross-presentation

Houde, M, Bertholet, S, Gagnon, E, Brunet, S, Goyette, G, Laplante, A, Princiotta, MF, Thibault, P, Sacks, D, Desjardins, M

Nature 2003
14561893 Early phagosomes in dendritic cells form a cellular compartment sufficient for cross presentation of exogenous antigens

Ackerman, AL, Kyritsis, C, Tampé, R, Cresswell, P

Proc Natl Acad Sci U S A 2003
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