Reactome | MmpL7 transports PDIM from the cytosol to the cell wall

MmpL7 transports PDIM from the cytosol to the cell wall

Stable Identifier

R-MTU-9637589

Type

Reaction [transition]

Species

Mycobacterium tuberculosis

Compartment

cytosol, peptidoglycan-based cell wall, plasma membrane

ReviewStatus

5/5

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MmpL7 transports PDIM from the cytosol to the cell wall

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Among the main constituents of the Mtb outer cell wall are phthiocerol dimycocerosates (PDIM). After biosynthesis PDIM get exported though the inner cell membrane by the phthiocerol dimycocerosate exporter MmpL7 efflux pump (MmpL7) (Cox et al. 1999; Szekely and Cole 2016).

Literature References

PubMed ID	Title	Journal	Year
26710752	Mechanistic insight into mycobacterial MmpL protein function Cole, ST, Székely, R	Mol. Microbiol.	2016
10573420	Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice Jacobs, WR, McNeil, M, Chen, B, Cox, JS	Nature	1999