PapA5 transforms mycocerosyl to PDIM

Stable Identifier
R-MTU-9635440
Type
Reaction [transition]
Species
Mycobacterium tuberculosis
Compartment
cytosol
Synonyms
2 mycocerosyl + phthiocerol => dimycocerosyl phthiocerol + 2 Pks5
ReviewStatus
5/5
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PapA5 transforms mycocerosyl to PDIM
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Mtb PapA5 catalyzes the transesterification of mycocerosyl. This protein catalyzes the synthesis of dimycocerosyl phthiocerol from mycocerosyl and phthiocerol (Trivedi et al. 2005).
Literature References
PubMed ID Title Journal Year
15749014 Dissecting the mechanism and assembly of a complex virulence mycobacterial lipid

Ansari, MZ, Arora, P, Gokhale, RS, Mohanty, D, Tickoo, R, Vats, A, Sridharan, V, Trivedi, OA

Mol. Cell 2005
Participants
Input
Output
Participates
as an event of
Catalyst Activity

transferase activity of PapA5 [cytosol]

Physical Entity
PapA5 [cytosol] (Mycobacterium tuberculosis)
Activity
transferase activity (GO:0016740)
Authored
Pardo, AM  (2019-02-13)
Koile, I  (2019-02-13)
Reviewed
Stephan, R  (2019-02-13)
Created
Pardo, AM  (2019-02-05)
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