FadD26, FadD28 transfer LCFA adenylate ester to Pks5

Stable Identifier
R-MTU-9635428
Type
Reaction [transition]
Species
Mycobacterium tuberculosis
Compartment
Synonyms
2 Pks5 + 2 LCFA adenylate ester=>2 LCFA:Pks5 + 2 AMP + 2 H+
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Mtb FadD proteins (FadD26 and FadD28) are a class of long-chain fatty acyl-AMP ligases (FAALs) that bind activated fatty acids (LCFA adenylate esters) to polyketide synthase Pks5 (Pks5). This binding has the effect of activating fatty acids for further chain extension (Trivedi et al. 2004).

Literature References
PubMed ID Title Journal Year
15042094 Enzymic activation and transfer of fatty acids as acyl-adenylates in mycobacteria

Trivedi, OA, Arora, P, Sridharan, V, Tickoo, R, Mohanty, D, Gokhale, RS

Nature 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
adenylyltransferase activity of FadD26, FadD28 [cytosol]
Physical Entity
Activity
Authored
Reviewed
Created
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