Sulfhydrylation of O-acetylserine (OAS) is a four step process, as was shown with CysK1, consisting of 1) addition of OAS to pyridoxal phosphate, 2) deacetylation, 3) sulfhydrylation and 4) cleavage of cysteine. It remains to be shown that the enzyme binds to CysE, resulting in a bifunctional complex. Activity of CysK1 is not essential for M. tuberculosis (Schnell et al, 2007).
Oehlmann, W, Singh, M, Schneider, G, Schnell, R
cysteine synthase activity of CysK1 dimer [cytosol]
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