Reactome | glucose-6-phosphate is converted to inositol-1-phosphate

glucose-6-phosphate is converted to inositol-1-phosphate

Stable Identifier

R-MTU-879331

Type

Reaction [transition]

Species

Mycobacterium tuberculosis

Compartment

cytosol

ReviewStatus

5/5

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glucose-6-phosphate is converted to inositol-1-phosphate

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M. tuberculosis utilizes myo-inositol-1-phosphate for mycothiol biosynthesis. This substrate comes nearly exclusively from the conversion of glucose-6-phosphate by Ino1. However, mutants devoid of Ino1 still have minimal amounts of mycothiol, so another reaction appears to provide Ins-P in small amounts, most likely the phosphorylation of uptaken inositol (Bachhawat and Mande, 1999; Mohavedzadeh et al, 2004; Newton et al, 2006; Newton et al, 2008).

Literature References

PubMed ID	Title	Journal	Year
12005437	Crystal structure of inositol 1-phosphate synthase from Mycobacterium tuberculosis, a key enzyme in phosphatidylinositol synthesis Norman, RA, Murray-Rust, J, Stoker, NG, McAlister, MS, McDonald, NQ, Movahedzadeh, F	Structure	2002
18772286	Biosynthesis and functions of mycothiol, the unique protective thiol of Actinobacteria Newton, GL, Fahey, RC, Buchmeier, N	Microbiol Mol Biol Rev	2008
10448034	Identification of the INO1 gene of Mycobacterium tuberculosis H37Rv reveals a novel class of inositol-1-phosphate synthase enzyme Mande, SC, Bachhawat, N	J Mol Biol	1999
14763976	The Mycobacterium tuberculosis ino1 gene is essential for growth and virulence Kendall, SL, Bancroft, GJ, Murray-Rust, J, Stoker, NG, McAlister, MS, McDonald, NQ, Russell, DG, Av-Gay, Y, Daffe, M, Rison, SC, Norman, RA, Smith, DA, Dinadayala, P, Movahedzadeh, F	Mol Microbiol	2004