acetylglucosamine-inositol is deacetylated by Mca

Stable Identifier
R-MTU-879327
Type
Reaction [transition]
Species
Mycobacterium tuberculosis
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
A small part of deacetylase activity required in the step producing glucosaminylinositol comes from the mycothiol S-conjugate amidase Mca. The hydrolaswe also needs zinc for its activity (Steffek et al, 2003).
Literature References
PubMed ID Title Journal Year
12958317 The crystal structure of 1-D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis reveals a zinc hydrolase with a lactate dehydrogenase fold

Arad, D, James, MN, Garen, C, Newton, G, Maynes, JT, Fahey, RC, Av-Gay, Y, Cherney, MM

J Biol Chem 2003
14556638 Characterization of Mycobacterium tuberculosis mycothiol S-conjugate amidase

Newton, GL, Fahey, RC, Av-Gay, Y, Steffek, M

Biochemistry 2003
11092856 N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) is a key enzyme in mycothiol biosynthesis

Newton, GL, Fahey, RC, Av-Gay, Y

J Bacteriol 2000
Participants
Participates
Catalyst Activity

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds of mca:Zn2+ [cytosol]

Authored
Reviewed
Created
Cite Us!