mycothione is reduced to mycothiol

Stable Identifier
R-MTU-879322
Type
Reaction
Species
Mycobacterium tuberculosis
Compartment
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Mycothiol is recycled using a reduction equivalent (NADPH/H+) and the help of the mycothione reductase enzyme. Although a mtr null mutant was obtained by McAdam and coworkers in M. tuberculosis, another study by Sassetti suggests the enzyme is essential in the H37Rv strain. It appears possible that thioredoxin reductases can provide some enzymatic rest activity. (Patel and Blanchard, 1999; Rawat and Av-Gay, 2007)

Literature References
PubMed ID Title Journal Year
17286835 Mycothiol-dependent proteins in actinomycetes

Rawat, M, Av-Gay, Y

FEMS Microbiol Rev 2007
10512639 Expression, purification, and characterization of Mycobacterium tuberculosis mycothione reductase

Patel, MP, Blanchard, JS

Biochemistry 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
mycothione reductase activity of Mtr [cytosol]
Physical Entity
Activity
Cross References
Target Pathogen
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