Npas4 stimulates Gem gene expression

Stable Identifier
R-MMU-9927155
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Npas4 stimulates Gem gene expression
In a mouse model system, Gem gene was identified as an Npas4 target gene which is induced by Npas4 and promotes neuroprotection after ischemic brain injury (Takahashi et al. 2021).
Literature References
PubMed ID Title Journal Year
34349016 Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke

Takahashi, H, Tsuboi, A, Kato, S, Hioki, H, Matsui, TK, Yamamoto, T, Fujioka, M, Mori, E, Kobayashi, K, Asahina, R

Proc Natl Acad Sci U S A 2021
Participants
Input
Output
This event is regulated
Positively by
Regulator
(Npas4:Arntl,Npas4:Arnt,Npas4:Arnt2) [nucleoplasm] (Mus musculus)
Active Unit
(Npas4:Arntl,Npas4:Arnt,Npas4:Arnt2) [nucleoplasm]
Orthologous Events
NPAS4 stimulates GEM gene expression (Homo sapiens)
Authored
Orlic-Milacic, M  (2022-04-08)
Reviewed
Matthews, L  (2024-11-11)
Lin, Y  (2022-07-29)
Created
Orlic-Milacic, M  (2024-11-04)
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