Reactome | Cebpa gebe expression is stimulated by Pparg and Mll4,(Mll3) complex

Cebpa gebe expression is stimulated by Pparg and Mll4,(Mll3) complex

Stable Identifier

R-MMU-9858204

Type

Reaction [omitted]

Species

Mus musculus

Compartment

nucleoplasm

ReviewStatus

3/5

General

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SVG | | PPTX | SBGN

Cebpa gebe expression is stimulated by Pparg and Mll4,(Mll3) complex

In mouse embryonic fibroblasts (MEFs) in which Pparg was ectopically expressed, Pparg positively regulates Cebpa transcription in a ligand-dependent manner (Ge et a. 2008).

MEFs deficient for Paxip1 (Ptip), an accessory subunit of Kmt2c (Mll3) and Kmt2d (Mll4) complexes, show a severe defect in Pparg- and ligand-stimulated expression of endogenous Cebpa (Cho et al. 2009). In differentiating mouse brown preadipocytes, Paxip1 promotes recruitment of RNA Pol II to Cebpa gene promoter (Cho et al. 2009).

In mouse brown preadipocytes expressing histone 3 mutant H3.3 K4M, the expression of the Cebpa gene is severely reduced (Jang et al. 2019). Deletion of SET domains of Kmt2c and Kmt2d in mouse brown preadipocytes prevents induction of Cebpa during adipogenesis (Jang et al. 2019).

Literature References

PubMed ID	Title	Journal	Year
30335158	H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development Park, YK, Lee, JE, Froimchuk, E, Jang, Y, Broun, A, Wang, C, Liu, C, Zhuang, L, Ge, K	Nucleic Acids Res	2019
18039840	Alternative mechanisms by which mediator subunit MED1/TRAP220 regulates peroxisome proliferator-activated receptor gamma-stimulated adipogenesis and target gene expression Hong, TB, Guermah, M, Cho, YW, Ge, K, Kalkum, M, Yu, H, Ito, M, Roeder, RG, Guo, H	Mol Cell Biol	2008
19583951	Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis Ge, K, Wang, L, Hong, S, Gavrilova, O, Lee, JE, Jin, Q, Cho, YW	Cell Metab	2009