Reactome | Expression of Pax2 in metanephric mesenchyme

Expression of Pax2 in metanephric mesenchyme

Stable Identifier

R-MMU-9831823

Type

Reaction [omitted]

Species

Mus musculus

Compartment

nucleoplasm

ReviewStatus

3/5

General

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SVG | | PPTX | SBGN

Expression of Pax2 in metanephric mesenchyme

Pax2 is first expressed in the intermediate mesoderm on embryonic day 8.5 (E8.5) then in the nephric duct and metanephric mesenchyme of the developing kidney at E10.5 (Dressler et al. 1990, Torres et al. 1995, Xu et al. 2003). Mice lacking Pax2 fail to form ureteric buds or metanephric kidneys (Torres et al. 1995, Brophy et al. 2001) due to a failure to activate expression of the signaling molecule glial cell-derived neurotrophic factor (Gdnf) (Brophy et al. 2001). Expression of Pax2 in metanephric mesenchyme is activated by Six1 and absence of Six1 causes a large reduction but not a total loss of Pax2 (Xu et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
8575306	Pax-2 controls multiple steps of urogenital development Torres, M, Gruss, P, Dressler, GR, Gómez-Pardo, E	Development	1995
12783782	Six1 is required for the early organogenesis of mammalian kidney Xu, PX, Silvius, D, Zheng, W, Huang, L, Laclef, C, Maire, P	Development	2003
11731455	Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene Lang, KM, Dressler, GR, Brophy, PD, Ostrom, L	Development	2001