Eya1, Pax2, and Hox11 paralog bind the Gdnf gene

Stable Identifier
R-MMU-9830938
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
3/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Eya1, Pax2, and Hox11 paralog bind the Gdnf gene
Hoxa11 (or Hoxc11 or Hoxd11), Eya1, and Pax2 physically interact to form a complex (Gong et al. 2007) which binds the Gdnf gene (inferred from results with the Six2 gene in Gong et al. 2007). The components of the Hox11:Eya1:Pax2 complex synergistically activate expression of Gdnf (Gong et al. 2007).
Literature References
PubMed ID Title Journal Year
17785448 A Hox-Eya-Pax complex regulates early kidney developmental gene expression

Gong, KQ, Yallowitz, AR, Sun, H, Dressler, GR, Wellik, DM

Mol Cell Biol 2007
Participants
Input
Output
Orthologous Events
EYA1, PAX2, and HOX11 paralog bind the GDNF gene (Homo sapiens)
Authored
May, B  (2023-03-15)
Created
May, B  (2023-03-17)
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