Ripply2 binds Tbx6 and recruits the 26S proteasome

Stable Identifier
R-MMU-9825547
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Ripply2 binds Tbx6 and recruits the 26S proteasome
Ripply2 inhibits Tbx6 activity post-translationally (Takahashi et al. 2010, Zhao et al. 2015) by binding Tbx6 and recruiting the proteasome to degrade Tbx6 (Zhao et al. 2018). Tbx6 is ubiquitinated by an unknown mechanism prior to degradation (Zhao et al. 2018).
Literature References
PubMed ID Title Journal Year
29761784 Ripply2 recruits proteasome complex for Tbx6 degradation to define segment border during murine somitogenesis

Saga, Y, Oginuma, M, Okubo, A, Ajima, R, Kiso, M, Zhao, W

Elife 2018
Participants
Input
Output
Orthologous Events
RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)
Authored
May, B  (2023-01-25)
Reviewed
Yamaguchi, TP  (2023-05-09)
Chalamalasetty, RB  (2023-05-09)
Created
May, B  (2023-01-26)
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