Msgn1 binds the Notch1 gene

Stable Identifier
R-MMU-9824233
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Msgn1 binds the Notch1 gene
Wnt3a signaling activates the Mesogenin1 (Msgn1) gene via the binding of Lef1:Ctnnb1 (Lef1:beta-catenin) to the promoter of the Msgn1 gene (Chalamalasetty et al. 2011). Msgn1 then binds two sites in the promoter of the Notch1 gene (Chalamalasetty et al. 2011, Chalamalasetty et al. 2014).
Literature References
PubMed ID Title Journal Year
25371364 Mesogenin 1 is a master regulator of paraxial presomitic mesoderm differentiation

Chalamalasetty, RB, Garriock, RJ, Dunty, WC, Kennedy, MW, Jailwala, P, Si, H, Yamaguchi, TP

Development 2014
21750544 The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program

Chalamalasetty, RB, Dunty, WC, Biris, KK, Ajima, R, Iacovino, M, Beisaw, A, Feigenbaum, L, Chapman, DL, Yoon, JK, Kyba, M, Yamaguchi, TP

Nat Commun 2011
Participants
Input
Output
Orthologous Events
MSGN1 binds the NOTCH1 gene (Homo sapiens)
Authored
Chalamalasetty, RB  (2022-11-09)
Yamaguchi, TP  (2022-11-09)
Reviewed
May, B  (2023-05-12)
Created
May, B  (2023-01-18)
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