Hes7 binds the Lfng gene

Stable Identifier
R-MMU-9824230
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Hes7 binds the Lfng gene
The Hairy and enhancer of split 7 (Hes7) protein binds 4 N-boxes in the promoter of the Lunatic fringe (Lfng) gene and represses activation of Lfng by Notch signaling (Bessho et al. 2001, Chen et al. 2005). Cyclic expression of Hes7 (Bessho et al. 2001) and repression of Notch signaling by Lfng (inferred from chicken homologs in Dale et al. 2003) cause cyclic expression of Lfng during somite formation.
Literature References
PubMed ID Title Journal Year
12783854 Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock

Hirata, H, Bessho, Y, Masamizu, Y, Kageyama, R

Genes Dev 2003
16342160 Negative feedback loop formed by Lunatic fringe and Hes7 controls their oscillatory expression during somitogenesis

Kang, L, Chen, J, Zhang, N

Genesis 2005
Participants
Input
Output
Orthologous Events
HES7 binds the LFNG gene (Homo sapiens)
Authored
Chalamalasetty, RB  (2022-11-09)
Yamaguchi, TP  (2022-11-09)
Reviewed
May, B  (2023-05-12)
Created
May, B  (2023-01-18)
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