Expression of Gsc in definitive endoderm

Stable Identifier
R-MMU-9823980
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Gsc in definitive endoderm
During gastrulation Goosecoid (Gsc) is expressed at the anterior end of the primitive streak (Blum et al. 1992) then in the foregut endoderm (Belo et al. 1998). Mixl1 binds two elements in the upstream promoter of the Gsc gene and activates transcription (Lim et al. 2009). In mouse embryonic stem cells, expression of Gsc responds to high concentrations of Activin/Nodal signaling and this is dependent on Fgf signaling but not Wnt signaling (Hansson et al. 2009).
Literature References
PubMed ID Title Journal Year
19358838 A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells

Kahn, M, Engberg, N, Winzi, M, Olesen, DR, Maddox-Hyttel, P, Klein, T, Hansson, M, Peterslund, JM, Serup, P

Dev Biol 2009
19038793 Enforced expression of Mixl1 during mouse ES cell differentiation suppresses hematopoietic mesoderm and promotes endoderm formation

Wong, MS, Trounson, A, Lim, SM, Stanley, EG, Van Vranken, BE, Elefanty, AG, Hirst, CE, Pick, M, Pereira, L

Stem Cells 2009
9533949 The prechordal midline of the chondrocranium is defective in Goosecoid-1 mouse mutants

Belo, JA, Leyns, L, De Robertis, EM, Yamada, G

Mech Dev 1998
1352187 Gastrulation in the mouse: the role of the homeobox gene goosecoid

Blumberg, B, Steinbeisser, H, De Robertis, EM, Gaunt, SJ, Blum, M, Cho, KW, Bittner, D

Cell 1992
Participants
Input
Output
This event is regulated
Positively by
Regulator
Mixl1:Gsc gene [nucleoplasm] (Mus musculus)
Orthologous Events
Expression of GSC in definitive endoderm (Homo sapiens)
Authored
May, B  (2023-01-11)
Reviewed
Tam, PPL  (2023-02-28)
Salehin, N  (2023-02-28)
Created
May, B  (2023-01-13)
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