Kdm6a (Utx) demethylates trimethylated histone H3 lysine-27 (H3K27me3)

Stable Identifier
R-MMU-9822964
Type
Reaction [transition]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
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PNG
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Medium
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 | PPTX  | SBGN
Kdm6a (Utx) demethylates trimethylated histone H3 lysine-27 (H3K27me3)
Kdm6a (UTX) demethylates histone H3 trimethyllysine-27 (H3K27me3, lysine-28 of the preprotein) to yield histone H3 monomethyllysine-27 (H3K27me1) (inferred from the human homolog). Kdm6a participates in demethylating genome-wide H3K27me3 in cleavage stage embryos (Bai et al. 2019).
Literature References
PubMed ID Title Journal Year
31595154 Histone Demethylase UTX is an Essential Factor for Zygotic Genome Activation and Regulates Zscan4 Expression in Mouse Embryos

Bai, L, Yang, L, Zhao, C, Song, L, Liu, X, Bai, C, Su, G, Wei, Z, Li, G

Int J Biol Sci 2019
Participants
Input
Output
Catalyst Activity

histone H3K27me2/H3K27me3 demethylase activity of Kdm6a:Fe2+ [nucleoplasm]

Physical Entity
Kdm6a:Fe2+ [nucleoplasm] (Mus musculus)
Activity
histone H3K27me2/H3K27me3 demethylase activity (GO:0071558)
Orthologous Events
KDM6A (UTX) demethylates histone H3 trimethyllysine-27 (H3K27me3) (Homo sapiens)
Authored
May, B  (2022-12-28)
Reviewed
Xie, W  (2023-08-08)
Created
May, B  (2023-01-03)
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