Npm2 and Hira bind p-S9,S43-Prm1:dsDNA

Stable Identifier
R-MMU-9822106
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Npm2 and Hira bind p-S9,S43-Prm1:dsDNA
Npm2 and Hira bind phosphorylated Prm1 (Gou et al. 2020). Npm2 and Hira may also bind phosphorylated Prm2, however this was not assayed and is not annotated here. Npm2 can bind either protamines or histones (Ellard et al. 2016)
Literature References
PubMed ID Title Journal Year
32169215 Initiation of Parental Genome Reprogramming in Fertilized Oocyte by Splicing Kinase SRPK1-Catalyzed Protamine Phosphorylation

Gou, LT, Adams, JA, Zhao, J, Lim, DH, Li, H, Meng, F, Hao, Y, Rosenfeld, MG, Li, D, Ma, W, Liang, Z, Fu, XD, Liu, MF, Shao, C, Zhang, X, Wang, X, Aubol, BE, Mellon, PL, Xu, R, Zhang, X

Cell 2020
28955874 Expression and purification of the full murine NPM2 and study of its interaction with protamines and histones

Petrotchenko, EV, Ellard, K, Ausió, J, Borchers, CH, Serpa, JJ

Biochem Biophys Rep 2016
Participants
Input
Output
Orthologous Events
NPM2 and HIRA bind p-S9-PRM1:dsDNA (Homo sapiens)
Authored
May, B  (2022-12-18)
Reviewed
Xie, W  (2023-08-08)
Created
May, B  (2022-12-19)
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