Zfp36l2 binds Cnot6l of CCR4-CNOT complex and an AU-rich element in mRNA

Stable Identifier
R-MMU-9819258
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Zfp36l2 binds Cnot6l of CCR4-CNOT complex and an AU-rich element in mRNA
In maturing oocytes Zfp36l2 binds AU-rich elements in specific maternal mRNAs and also Cnot6l, a catalytic component of the CCR4-NOT RNA deadenylase complex (Sha et al. 2018). Knockout of Cnot6l prevents degradation of maternal transcripts related to translation (Sha et al. 2018) in maturing oocytes. Depletion or knockout of Zfp36l2 causes defects in oocyte maturation (Chousal et al. 2018, Sha et al. 2018) and prevents degradation of maternal mRNAs related to histone demethylation and regulation of transcription (Chousal et al. 2018), therefore Zfp36l2 is believed to regulate degradation of specific mRNAs in oocytes.
Literature References
PubMed ID Title Journal Year
29408237 Chromatin Modification and Global Transcriptional Silencing in the Oocyte Mediated by the mRNA Decay Activator ZFP36L2

Cho, K, Chousal, J, Stumpo, DJ, Cook-Andersen, H, Wilkinson, MF, Blackshear, PJ, Ramaiah, M, Laurent, LC, Mora-Castilla, S, Lykke-Andersen, J, Skarbrevik, D

Dev Cell 2018
30478191 CNOT6L couples the selective degradation of maternal transcripts to meiotic cell cycle progression in mouse oocyte

Yu, C, Zhang, YL, Jiang, JC, Jiang, Y, Zhang, SY, Dai, XX, Guo, JX, Fan, HY, Shen, L, Ou, XH, Yu, JL, Ji, SY, Sha, QQ

EMBO J 2018
Participants
Input
Output
Orthologous Events
ZFP36L2 binds CNOT6L of CCR4-CNOT complex and an AU-rich element in mRNA (Homo sapiens)
Authored
May, B  (2022-10-30)
Reviewed
Xie, W  (2023-08-08)
Created
May, B  (2022-11-02)
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