Aicda deaminates cytidine in chromatin containing histone H3.3 and 5-methylcytidine

Stable Identifier
R-MMU-9817520
Type
Reaction [transition]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Aicda deaminates cytidine in chromatin containing histone H3.3 and 5-methylcytidine
The first phase of active DNA demethylation in the male pronucleus is initiated by deamination of 5-methylcytidine by Aicda (AID), which produces a U-G mismatch that is repaired by the long patch base excision repair pathway to yield a C-G base pair (Santos et al. 2013, Franchini et al. 2014). Deamination of a cytidine residue adjacent to a 5-methylcytidine residue can also result in replacement of 5-methylcytidine with cytidine if the repair patch encompasses the 5-methylcytidine residue (Franchini et al. 2014). The net effect is DNA demethylation.
Literature References
PubMed ID Title Journal Year
25025377 Processive DNA demethylation via DNA deaminase-induced lesion resolution

Franchini, DM, Chan, CF, Morgan, H, Incorvaia, E, Rangam, G, Dean, W, Santos, F, Reik, W, Petersen-Mahrt, SK

PLoS One 2014
24279473 Active demethylation in mouse zygotes involves cytosine deamination and base excision repair

Santos, F, Peat, J, Burgess, H, Rada, C, Reik, W, Dean, W

Epigenetics Chromatin 2013
Participants
Input
Output
Catalyst Activity

cytidine deaminase activity of Aicda [nucleoplasm]

Physical Entity
Aicda [nucleoplasm] (Mus musculus)
Activity
cytidine deaminase activity (GO:0004126)
Orthologous Events
AICDA deaminates cytidine in chromatin containing histone H3.3 and 5-methylcytidine (Homo sapiens)
Authored
May, B  (2022-09-21)
Reviewed
Xie, W  (2023-08-08)
Created
May, B  (2022-09-23)
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