Dppa3 binds histone H3K9me2 in chromatin

Stable Identifier
R-MMU-9817490
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Dppa3 binds histone H3K9me2 in chromatin
Dppa3 (also called STELLA or PGC7) binds dimethylated lysine-9 of histone H3 (H3K9me2, lysine-10 of the preprotein) that is present in the maternal genome but not the paternal genome of the zygote (Santos et al. 2005, Wossidlo et al. 2011, Nakamura et al. 2012). Dppa3 prevents Tet3 from oxidizing 5-methylcytidine to 5-hydroxymethylcytidine and thereby blocks one pathway of active DNA methylation in the female pronucleus (Nakamura et al. 2012).
Literature References
PubMed ID Title Journal Year
21407207 5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming

Nakano, T, Reik, W, Walter, J, Zakhartchenko, V, Arand, J, Nakamura, T, Wossidlo, M, Lepikhov, K, Boiani, M, Marques, CJ

Nat Commun 2011
22722204 PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos

Nakano, T, Umehara, H, Shinkai, Y, Liu, YJ, Tachibana, M, Matoba, S, Nakashima, H, Nakamura, T, Ogura, A, Inoue, K

Nature 2012
Participants
Input
Output
Orthologous Events
DPPA3 binds histone H3K9me2 in chromatin (Homo sapiens)
Authored
May, B  (2022-09-18)
Reviewed
Xie, W  (2023-08-08)
Created
May, B  (2022-09-21)
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