Expression of Dux in the embryo

Stable Identifier
R-MMU-9816403
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Dux in the embryo
Dux is expressed during the initial, minor wave of zygotic genome activation at the 2-cell stage in mouse embryos. Transcription of Dux is directly activated by Dppa2 and Dppa4 (Eckersley-Maslin et al. 2019, De Iaco et al. 2019, Li et al. 2021). The mRNAs encoding Dppa2 and Dppa4 are maternally transmitted (De Iaco et al. 2019). Tp53 (p53) also participates in activation of Dux expression (Grow et al. 2021).
Literature References
PubMed ID Title Journal Year
34267371 p53 convergently activates Dux/DUX4 in embryonic stem cells and in facioscapulohumeral muscular dystrophy cell models

Grow, EJ, Weaver, BD, Smith, CM, Guo, J, Stein, P, Shadle, SC, Hendrickson, PG, Johnson, NE, Butterfield, RJ, Menafra, R, Kloet, SL, van der Maarel, SM, Williams, CJ, Cairns, BR

Nat Genet 2021
33316032 Dppa2/4 as a trigger of signaling pathways to promote zygote genome activation by binding to CG-rich region

Li, H, Long, C, Xiang, J, Liang, P, Li, X, Zuo, Y

Brief Bioinform 2021
30692203 Dppa2 and Dppa4 directly regulate the Dux-driven zygotic transcriptional program

Eckersley-Maslin, M, Alda-Catalinas, C, Blotenburg, M, Kreibich, E, Krueger, C, Reik, W

Genes Dev 2019
30948459 DPPA2 and DPPA4 are necessary to establish a 2C-like state in mouse embryonic stem cells

De Iaco, A, Coudray, A, Duc, J, Trono, D

EMBO Rep 2019
Participants
Input
Output
This event is regulated
Positively by
Regulator
Dppa2:Dppa4:p-S18-Tp53:Dux gene [nucleoplasm] (Mus musculus)
Orthologous Events
Expression of DUX4 in the zygote (Homo sapiens)
Authored
May, B  (2022-09-07)
Reviewed
Xie, W  (2023-08-08)
Created
May, B  (2022-09-12)
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