Reactome | Expression of Dll3 in paraxial mesoderm

Expression of Dll3 in paraxial mesoderm

Stable Identifier

R-MMU-9793917

Type

Reaction [omitted]

Species

Mus musculus

Compartment

endosome membrane, nucleoplasm

ReviewStatus

5/5

General

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Dll3 is a divergent Delta-like gene that encodes an inhibitory ligand of Notch and is expressed in the primitive streak and the entire mesoderm then becomes restricted to the paraxial mesoderm at the late primitive streak stage (Dunwoodie et al. 1997, Geffers et al. 2007). The pudgy allele of Dll3 disrupts somitogenesis and causes severe rib and vertebral deformities (Kusumi et al. 1998, Kusumi et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
9662403	The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundaries Kusumi, K, Sun, ES, Kerrebrock, AW, Bronson, RT, Chi, DC, Bulotsky, MS, Spencer, JB, Birren, BW, Frankel, WN, Lander, ES	Nat Genet	1998
17664336	Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo Geffers, I, Serth, K, Chapman, G, Jaekel, R, Schuster-Gossler, K, Cordes, R, Sparrow, DB, Kremmer, E, Dunwoodie, SL, Klein, T, Gossler, A	J Cell Biol	2007
9272948	Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo Dunwoodie, SL, Henrique, D, Harrison, SM, Beddington, RS	Development	1997
15170697	Dll3 pudgy mutation differentially disrupts dynamic expression of somite genes Kusumi, K, Mimoto, MS, Covello, KL, Beddington, RS, Krumlauf, R, Dunwoodie, SL	Genesis	2004