Expression of Dll1 in paraxial mesoderm

Stable Identifier
R-MMU-9793915
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Dll1 in paraxial mesoderm
Delta-like 1 (Dll1) is expressed in paraxial (presomitic) mesoderm and then becomes confined to caudal halves of somites during somitogenesis (Bettenhausen et al. 1995, Teppner et al. 2007). Expression of Dll1 is activated by Wnt signaling in paraxial mesoderm (Dunty et al. 2008) via Lef1, which binds multiple sites in the DLL1 promoter and recruits beta-catenin (Ctnnb1) (Galceran et al. 2004, Hofmann et al. 2004). Tbx6 also directly activates Dll1 expression in paraxial mesoderm (Hofmann et al. 2004, White and Chapman 2005, Beckers et al. 2000). Expression of Dll1 on the cell surface of paraxial mesoderm cells is oscillatory (Bone et al. 2014, Takagi et al. 2020). Presenilin 1 (Psen1) is required for expression of Dll1 and Notch1 in the paraxial mesoderm (Wong et al. 1997).
Literature References
PubMed ID Title Journal Year
15545628 WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos

Watabe-Rudolph, M, Gossler, A, Schuster-Gossler, K, Aulehla, A, Hofmann, M, Herrmann, BG

Genes Dev 2004
17572911 Compartmentalised expression of Delta-like 1 in epithelial somites is required for the formation of intervertebral joints

Teppner, I, Becker, S, Gossler, A, Beckers, J, De Angelis, MH

BMC Dev Biol 2007
15986483 Dll1 is a downstream target of Tbx6 in the paraxial mesoderm

White, PH, Chapman, DL

Genesis 2005
7671806 Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta

Gossler, A, Simon, D, Hrabĕ de Angelis, M, Bettenhausen, B, Guenet, JL

Development 1995
31899345 Dynamic Delta-like1 expression in presomitic mesoderm cells during somite segmentation

Yoshioka-Kobayashi, K, Kageyama, R, Isomura, A, Takagi, A

Gene Expr Patterns 2020
9153393 Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

Wong, PC, Van der Ploeg, LH, Chen, H, Chen, HY, Trumbauer, ME, Becher, MW, Zheng, H, Price, DL, Sirinathsinghji, DJ, Sisodia, SS

Nature 1997
15545629 LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis

Folberth, S, Hsu, SC, Galceran, J, Sustmann, C, Grosschedl, R

Genes Dev 2004
10906448 The mouse rib-vertebrae mutation disrupts anterior-posterior somite patterning and genetically interacts with a Delta1 null allele

Gossler, A, Schlautmann, N, Beckers, J

Mech Dev 2000
18045842 Wnt3a/beta-catenin signaling controls posterior body development by coordinating mesoderm formation and segmentation

Chalamalasetty, RB, Yamaguchi, TP, Biris, KK, Dunty, WC, Lewandoski, M, Taketo, MM

Development 2008
25468943 Spatiotemporal oscillations of Notch1, Dll1 and NICD are coordinated across the mouse PSM

Bailey, CS, Bone, RA, Murray, PJ, Appleton, PL, Maroto, M, Ferjentsik, Z, Dale, JK, Wiedermann, G

Development 2014
Participants
Input
Output
This event is regulated
Positively by
Regulator
Tbx6:Lef1:Ctnnb1:Dll1 gene [nucleoplasm] (Mus musculus)
Regulator
Tbxt [nucleoplasm] (Mus musculus)
Orthologous Events
Expression of DLL1 in paraxial mesoderm (Homo sapiens)
Authored
May, B  (2022-06-19)
Reviewed
Yamaguchi, TP  (2023-05-09)
Chalamalasetty, RB  (2022-11-09)
Yamaguchi, TP  (2022-11-09)
Chalamalasetty, RB  (2023-05-09)
Created
May, B  (2022-06-24)
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