Expression of Tbx6 in paraxial mesoderm

Stable Identifier
R-MMU-9793405
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Tbx6 in paraxial mesoderm
Tbx6 is expressed in the primitive streak and then expression continues in the paraxial mesoderm (Chapman et al. 1996). Notch signaling acting through Rbpj activates expression of Tbx6 in paraxial mesoderm (White et al. 2005). Wnt signaling (Dunty et al. 2008, Nowotschin et al. 2012) and Fgf signaling (Ciruna and Rossant 2001) also directly or indirectly activate expression of Tbx6 in paraxial mesoderm. Tbxt is not required for initial activation of Tbx6 expression, but Tbxt is required for maintenance of Tbx6 expression (Chapman et al. 1996). Mesogenin1 (Msgn1), which is itself activated by Tbx6, activates Tbx6 in a reinforcing loop (Chalamalasetty et al. 2014).
Literature References
PubMed ID Title Journal Year
8954725 Tbx6, a mouse T-Box gene implicated in paraxial mesoderm formation at gastrulation

Hancock, S, Silver, LM, Chapman, DL, Papaioannou, VE, Agulnik, I

Dev Biol 1996
25371364 Mesogenin 1 is a master regulator of paraxial presomitic mesoderm differentiation

Chalamalasetty, RB, Yamaguchi, TP, Jailwala, P, Kennedy, MW, Dunty, WC, Garriock, RJ, Si, H

Development 2014
15864811 Regulation of Tbx6 expression by Notch signaling

White, PH, Chapman, DL, Farkas, DR

Genesis 2005
18045842 Wnt3a/beta-catenin signaling controls posterior body development by coordinating mesoderm formation and segmentation

Chalamalasetty, RB, Yamaguchi, TP, Biris, KK, Dunty, WC, Lewandoski, M, Taketo, MM

Development 2008
11703922 FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak

Rossant, J, Ciruna, B

Dev Cell 2001
Participants
Input
Output
This event is regulated
Positively by
Regulator
Rbpj:Nicd:Tbx6 gene [nucleoplasm] (Mus musculus)
Active Unit
Rbpj [nucleoplasm]
Regulator
Wnt3a [extracellular region] (Mus musculus)
Regulator
Tbxt [nucleoplasm] (Mus musculus)
Regulator
Basic fibroblast growth factor receptor 1 [plasma membrane] (Mus musculus)
Regulator
Msgn1:Tbx6 gene [nucleoplasm] (Mus musculus)
Active Unit
Msgn1 [nucleoplasm]
Orthologous Events
Expression of TBX6 in paraxial mesoderm (Homo sapiens)
Authored
May, B  (2022-06-12)
Reviewed
Chalamalasetty, RB  (2022-11-09)
Yamaguchi, TP  (2022-11-09)
Created
May, B  (2022-06-12)
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