Npas4 binds promoters of Ins genes

Stable Identifier
R-MMU-9770099
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Npas4 binds promoters of Ins genes
In a mouse pancreatic beta cell-derived cell line, MIN6, Npas4 is induced by endoplasmic reticulum stress in pancreatic beta-cells and directly binds promoter sequences of both insulin genes, Ins1 and Ins2 (Sabatini et al. 2013).
Literature References
PubMed ID Title Journal Year
23656887 Npas4 is a novel activity-regulated cytoprotective factor in pancreatic β-cells

Zarrouki, B, Nian, C, Westwell-Roper, CY, Uy, RA, Sabatini, PV, Krentz, NA, Lynn, FC, Shapiro, AM, Poitout, V

Diabetes 2013
Participants
Input
Output
Orthologous Events
NPAS4 binds INS gene promoter (Homo sapiens)
Authored
Orlic-Milacic, M  (2022-04-08)
Reviewed
Lin, Y  (2022-07-29)
Created
Orlic-Milacic, M  (2022-03-24)
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