Npas4 stimulates Iqsec3 gene expression

Stable Identifier
R-MMU-9770014
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Npas4 stimulates Iqsec3 gene expression
In mouse GABAergic interneurons, Npas4 directly stimulates transcription of the Iqsec3 gene, encoding a GABAergic synapse-specific guanine nucleotide-exchange factor for ADP-ribosylation factor (ARF-GEF) (Kim et al. 2021).
Literature References
PubMed ID Title Journal Year
34289353 Npas4 regulates IQSEC3 expression in hippocampal somatostatin interneurons to mediate anxiety-like behavior

Um, JW, Kim, J, Tabuchi, K, Park, D, Ko, J, Kim, D, Cheong, E, Lee, D, Jeon, J, Jung, H, Mori, T, Kim, S, Kim, J, Hong, S, Kim, H

Cell Rep 2021
Participants
Input
Output
This event is regulated
Positively by
Regulator
(Npas4:Arntl,Npas4:Arnt,Npas4:Arnt2):Iqsec3 gene [nucleoplasm] (Mus musculus)
Active Unit
(Npas4:Arntl,Npas4:Arnt,Npas4:Arnt2) [nucleoplasm]
Orthologous Events
NPAS4 stimulates IQSEC3 gene expression (Homo sapiens)
Authored
Orlic-Milacic, M  (2022-04-08)
Reviewed
Lin, Y  (2022-07-29)
Created
Orlic-Milacic, M  (2022-03-23)
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