Reactome | Prl [extracellular region]

Prl [extracellular region]

Stable Identifier

R-MMU-976984

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

extracellular region

Synonyms

PRL, P06879

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Cytokine Signaling in Immune system (Mus musculus)
  - Growth hormone receptor signaling (Mus musculus)
    - JAK2 phosphorylation (Mus musculus)
      - Activated cytokine-like hormone receptors [plasma membrane] (Mus musculus)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Prl [extracellular region] (Mus musculus)
      - Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Prl [extracellular region] (Mus musculus)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Mus musculus)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Prl [extracellular region] (Mus musculus)
  - Prolactin receptor signaling (Mus musculus)
    - JAK2 phosphorylation (Mus musculus)
      - Activated cytokine-like hormone receptors [plasma membrane] (Mus musculus)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Prl [extracellular region] (Mus musculus)
      - Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Prl [extracellular region] (Mus musculus)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Mus musculus)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Prl [extracellular region] (Mus musculus)
    - PRLR activation (Mus musculus)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Prl [extracellular region] (Mus musculus)
    - PRLR binds SCF beta-TrCP complex (Mus musculus)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Mus musculus)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Prl [extracellular region] (Mus musculus)
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Prl [extracellular region] (Mus musculus)
    - PRLR is phosphorylated at Ser-349 (Mus musculus)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Prl [extracellular region] (Mus musculus)
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Prl [extracellular region] (Mus musculus)
    - Prolactin receptor is internalized (Mus musculus)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer [endosome lumen] (Mus musculus)
        
        2xp-S349-PRLR:2xJAK2 [endosome lumen] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Prl [extracellular region] (Mus musculus)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Mus musculus)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Prl [extracellular region] (Mus musculus)
    - Prolactin receptor ligands bind the prolactin receptor (Mus musculus)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Prl [extracellular region] (Mus musculus)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Mus musculus)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Prl [extracellular region] (Mus musculus)
      - Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Prl [extracellular region] (Mus musculus)
    - SH2B binds JAK2 (Mus musculus)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Mus musculus)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Prl [extracellular region] (Mus musculus)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Prl [extracellular region] (Mus musculus)

External Reference Information

External Reference

UniProt:P06879

Gene Names

Prl

Reference Genes

ENSEMBL:ENSMUSG00000021342

ENSEMBL:ENSMUSG00000021342.15 Prl

Other Identifiers

10404264

1429287_a_at

17286107

19109

4312771

4737074

5059582

5107402

5133862

5182859

5227991

5358460

5524477

5547777

92803_at

A_51_P155514

A_55_P2160168

GE35938

GO:0001937

GO:0005148

GO:0005179

GO:0005576

GO:0005615

GO:0006351

GO:0006355

GO:0007165

GO:0007565

GO:0007595

GO:0008283

GO:0008284

GO:0022414

GO:0023052

GO:0030141

GO:0030278

GO:0030879

GO:0031410

GO:0031667

GO:0042711

GO:0043226

GO:0046425

GO:0046427

GO:0048018

GO:0048856

GO:0050673

GO:0050679

GO:0098772

GO:1902895

GO:1903489

ILMN_2685995

mMC011926

x02892_s_at

Participates

as a member of

Prolactin receptor ligands [extracellular region] (Mus musculus)

Other forms of this molecule

Prl [endosome lumen]

Inferred From

PRL [extracellular region] (Homo sapiens)

Cross References

Ensembl

ENSMUSP00000153245, ENSMUST00000224228, ENSMUSG00000021342

PRO

P06879

MGI

97762

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