Npas4 stimulates Fos gene transcription

Stable Identifier
R-MMU-9768949
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Npas4 stimulates Fos gene transcription
In mouse hippocampal neurons Npas4 directly stimulates Fos gene transcription (Ramamoorthi et al. 2011). In rat primary neurons, Fos gene transcription is significantly upregulated upon Npas4 activation (Brigidi et al. 2019).
Literature References
PubMed ID Title Journal Year
22194569 Npas4 regulates a transcriptional program in CA3 required for contextual memory formation

Otto, T, McKinney, RM, Ramamoorthi, K, Fitzmaurice, HL, Lin, Y, Neve, RL, Belfort, GM, Fropf, R

Science 2011
Participants
Input
Output
This event is regulated
Positively by
Regulator
(Npas4:Arntl,Npas4:Arnt,Npas4:Arnt2):Fos gene [nucleoplasm] (Mus musculus)
Active Unit
(Npas4:Arntl,Npas4:Arnt,Npas4:Arnt2) [nucleoplasm]
Orthologous Events
NPAS4 stimulates FOS gene expression (Homo sapiens)
Authored
Orlic-Milacic, M  (2022-04-08)
Reviewed
Lin, Y  (2022-07-29)
Created
Orlic-Milacic, M  (2022-03-15)
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