Reactome | Mdm2 gene expression is repressed by Npas4

Mdm2 gene expression is repressed by Npas4

Stable Identifier

R-MMU-9768929

Type

Reaction [omitted]

Species

Mus musculus

Compartment

nucleoplasm, cytosol

ReviewStatus

5/5

General

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Mdm2 gene expression is repressed by Npas4

In mouse olfactory bulb neurons, Npas4 directly represses transcription of Mdm2. Npas4-mediated repression of Mdm2 is needed to increase dendritic spine density through prevention of Mdm2-mediated ubiquitination and degradation of microtubule-associated protein Dcx (Yoshihara et al. 2014), involved in neuronal dispersion and lamination. In mouse hippocampus, Npas4 was also shown to negatively regulate Mdm2 expression, which interferes with Mdm2-mediated ubiquitination and degradation of the postsynaptic density protein Dlg4 (PSD-95) (Lv et al. 2021).

Literature References

PubMed ID	Title	Journal	Year
33411316	Neuroprotective Effects Against Cerebral Ischemic Injury Exerted by Dexmedetomidine via the HDAC5/NPAS4/MDM2/PSD-95 Axis Chen, W, Cheng, Q, Lv, H, Chen, J, Li, Y	Mol Neurobiol	2021
25088421	Npas4 regulates Mdm2 and thus Dcx in experience-dependent dendritic spine development of newborn olfactory bulb interneurons Takahashi, H, Tsuboi, A, Yoshihara, S, Kinoshita, M, Kitsuki, M, Hirai, H, Furukawa-Hibi, Y, Nagai, T, Tatsumi, K, Nishimura, N, Yamada, K, Asahina, R	Cell Rep	2014