Expression of Gata4 in lateral plate mesoderm

Stable Identifier
R-MMU-9759884
Type
Reaction [omitted]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Expression of Gata4 in lateral plate mesoderm
The Gata4 gene is transcribed to yield mRNA and the mRNA is transcribed to yield Gata4 protein. Foxf1 binds enhancers of the Gata4 gene and activates transcription of Gata4 (Rojas et al. 2005). Bmp4 is also required to activate Gata4 in the embryo (Rojas et al. 2005). Bmp4 activates Foxf1 and may act on Gata4 via Foxf1.
Literature References
PubMed ID Title Journal Year
15987774 Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element

Black, BL, Xu, SM, Bristow, J, Heidt, AB, De Val, S, Rojas, A

Development 2005
Participants
This event is regulated
Orthologous Events
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