Reactome | Expression of Bmp4 in lateral plate mesoderm

Expression of Bmp4 in lateral plate mesoderm

Stable Identifier

R-MMU-9759869

Type

Reaction [omitted]

Species

Mus musculus

Compartment

nucleoplasm

ReviewStatus

5/5

General

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SVG | | PPTX | SBGN

Expression of Bmp4 in lateral plate mesoderm

The Bmp4 gene is transcribed to yield mRNA and the mRNA is translated to yield Bmp4 protein. In lateral plate mesoderm, expression of Bmp4 is activated by Foxf1 (Astorga and Carlsson 2007) and then maintained by Gata4, which binds the Bmp4 promoter and is also a target of Foxf1 (Nemer and Nemer 2003, Rojas et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
12606287	Transcriptional activation of BMP-4 and regulation of mammalian organogenesis by GATA-4 and -6 Nemer, G, Nemer, M	Dev Biol	2003
15987774	Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element Rojas, A, De Val, S, Heidt, AB, Xu, SM, Bristow, J, Black, BL	Development	2005
17881493	Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4 Astorga, J, Carlsson, P	Development	2007

Participants

Input

Bmp4 gene [nucleoplasm] (Mus musculus)

Output

Bmp4 [extracellular region] (Mus musculus)

This event is regulated

Positively by

Regulator

Gata4:Bmp4 gene [nucleoplasm] (Mus musculus)

Active Unit

Gata4 [nucleoplasm]

Regulator

Foxf1 [nucleoplasm] (Mus musculus)

Orthologous Events

Expression of BMP4 in lateral plate mesoderm (Homo sapiens)

Authored

May, B (2021-12-14)

Reviewed

Mosimann, C (2022-11-09)

Prummel, KD (2022-11-09)

Created

May, B (2021-12-14)

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