Reactome | Asb5 [cytosol]

Asb5 [cytosol]

Stable Identifier

R-MMU-975420

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

ASB5, Q9D1A4

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - Class I MHC mediated antigen processing & presentation (Mus musculus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Mus musculus)
      - Interaction of E3 with substrate and E2-Ub complex (Mus musculus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb5 [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb5 [cytosol] (Mus musculus)
      - Polyubiquitination of substrate (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb5 [cytosol] (Mus musculus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb5 [cytosol] (Mus musculus)
        
        E3:Ub:substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb5 [cytosol] (Mus musculus)
      - Release of E3 from polyubiquitinated substrate (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb5 [cytosol] (Mus musculus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb5 [cytosol] (Mus musculus)
      - Transfer of Ub from E2 to substrate and release of E2 (Mus musculus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb5 [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb5 [cytosol] (Mus musculus)
        
        E3:Ub:substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb5 [cytosol] (Mus musculus)

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Neddylation (Mus musculus)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Mus musculus)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb5 [cytosol] (Mus musculus)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb5 [cytosol] (Mus musculus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Mus musculus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
        
        CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb5 [cytosol] (Mus musculus)
      - CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb5 [cytosol] (Mus musculus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
        
        CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb5 [cytosol] (Mus musculus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb5 [cytosol] (Mus musculus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb5 [cytosol] (Mus musculus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb5 [cytosol] (Mus musculus)
    - NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Mus musculus)
      - CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb5 [cytosol] (Mus musculus)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb5 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9D1A4

Gene Names

Asb5

Reference Genes

BioGPS Gene:76294 Asb5

ENSEMBL:ENSMUSG00000031519

ENSEMBL:ENSMUSG00000031519.5 Asb5

KEGG Gene (Mus musculus):76294 Asb5

Monarch:76294 Asb5

NCBI Gene:76294 Asb5

UCSC:Q9D1A4 Asb5

Reference Transcript

RefSeq:NM_029569.3 Asb5

Other Identifiers

10571797

1449356_at

163436_at

17501170

4307650

4589427

4726438

5000560

5007315

5037509

5065347

5211683

5336157

5397167

76294

A_51_P170827

GE125114

GO:0003674

GO:0005515

GO:0005575

GO:0016020

GO:0016567

GO:0023052

GO:0030163

GO:0035556

GO:0036211

GO:0045732

ILMN_2660728

mMC024078

Participates

as a member of

Inferred From

ASB5 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_083845.1

Ensembl

ENSMUSP00000033918, ENSMUSG00000031519, ENSMUST00000033918

PRO

Q9D1A4

MGI

1923544

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