Reactome | Asb11 [cytosol]

Asb11 [cytosol]

Stable Identifier

R-MMU-975415

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

ASB11, Q9CQ31

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - Class I MHC mediated antigen processing & presentation (Mus musculus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Mus musculus)
      - Interaction of E3 with substrate and E2-Ub complex (Mus musculus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb11 [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb11 [cytosol] (Mus musculus)
      - Polyubiquitination of substrate (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb11 [cytosol] (Mus musculus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb11 [cytosol] (Mus musculus)
        
        E3:Ub:substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb11 [cytosol] (Mus musculus)
      - Release of E3 from polyubiquitinated substrate (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb11 [cytosol] (Mus musculus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb11 [cytosol] (Mus musculus)
      - Transfer of Ub from E2 to substrate and release of E2 (Mus musculus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb11 [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb11 [cytosol] (Mus musculus)
        
        E3:Ub:substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb11 [cytosol] (Mus musculus)

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Neddylation (Mus musculus)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Mus musculus)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb11 [cytosol] (Mus musculus)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb11 [cytosol] (Mus musculus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Mus musculus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
        
        CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb11 [cytosol] (Mus musculus)
      - CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb11 [cytosol] (Mus musculus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
        
        CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb11 [cytosol] (Mus musculus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb11 [cytosol] (Mus musculus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb11 [cytosol] (Mus musculus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb11 [cytosol] (Mus musculus)
    - NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Mus musculus)
      - CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb11 [cytosol] (Mus musculus)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb11 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9CQ31

Gene Names

Asb11

Reference Genes

BioGPS Gene:68854 Asb11

ENSEMBL:ENSMUSG00000031382

ENSEMBL:ENSMUSG00000031382.15 Asb11

KEGG Gene (Mus musculus):68854 Asb11

Monarch:68854 Asb11

NCBI Gene:68854 Asb11

UCSC:Q9CQ31 Asb11

Reference Transcript

Other Identifiers

10603116

1422153_a_at

163438_at

17539560

4505431

4848183

5000196

5027877

5145959

5232370

5411403

5436370

5447849

5518400

5569815

5600054

68854

A_51_P125383

A_55_P2122618

A_55_P2122619

GE42879

GO:0003674

GO:0005515

GO:0005783

GO:0016567

GO:0023052

GO:0030163

GO:0035556

GO:0036211

GO:0043226

GO:0045732

ILMN_2632028

mMC013574

Participates

as a member of

Inferred From

ASB11 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_081129.1, NP_001300666.1

Ensembl

ENSMUST00000036858, ENSMUSP00000044637, ENSMUST00000033755, ENSMUSG00000031382, ENSMUSP00000033755

PRO

Q9CQ31

MGI

1916104

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