Kcnj2 transports K+ from the extracellular region to the cytosol

Stable Identifier
R-MMU-9729881
Type
Reaction [transition]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Kcnj2 transports K+ from the extracellular region to the cytosol
The Kcnj2 inward rectifying potassium channel preferentially transports K+ ions from the extracellular region to the cytosol (Ye et al. 2016). In type III taste cells, the increase in cytosolic H+ caused by acidic compounds inhibits the activity of KCNJ2 (Ye et al. 2016).
Literature References
PubMed ID Title Journal Year
26627720 The K+ channel KIR2.1 functions in tandem with proton influx to mediate sour taste transduction

Mulhall, EM, Liman, ER, Chick, WS, Hill-Eubanks, DC, Cooper, AJ, Nelson, MT, Ye, W, Kinnamon, SC, Chang, RB, Bushman, JD, Tu, YH, Wilson, CE

Proc Natl Acad Sci U S A 2016
Participants
Input
Output
Catalyst Activity

inward rectifier potassium channel activity of Kcnj2 [plasma membrane]

Physical Entity
Kcnj2 [plasma membrane] (Mus musculus)
Activity
inward rectifier potassium channel activity (GO:0005242)
This event is regulated
Negatively by
Regulator
H+ [cytosol]
Orthologous Events
KCNJ2 (KIR2.1) transports K+ from the extracellular region to the cytosol (Homo sapiens)
Authored
May, B  (2021-04-30)
Reviewed
Jiang, P  (2021-08-08)
Created
May, B  (2021-05-03)
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