Reactome | Calhm1:Calhm3 transports ATP from the cytosol to the extracellular region

Calhm1:Calhm3 transports ATP from the cytosol to the extracellular region

Stable Identifier

R-MMU-9717434

Type

Reaction [transition]

Species

Mus musculus

Compartment

plasma membrane

ReviewStatus

5/5

General

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SVG | | PPTX | SBGN

Calhm1:Calhm3 transports ATP from the cytosol to the extracellular region

The Calhm1 channel transports ATP across the plasma membrane in response to depolarization of the membrane (Taruno et al. 2013). Heteromeric complexes containing both Calhm1 and Calhm3 have voltage-gating that is faster than homomeric Calhm1 complexes and resembles the voltage gating observed in vivo (Ma et al. 2018). In mice, knockout of Calhm1 strongly affected voltage-gated currents associated with ATP release (Ma et al. 2017) and Calhm1 and Calhm3 are sorted to the basolateral membrane of taste cells (Kashio et al. 2019).

Literature References

PubMed ID	Title	Journal	Year
30804437	CALHM1/CALHM3 channel is intrinsically sorted to the basolateral membrane of epithelial cells including taste cells Kido, MA, Wei-Qi, G, Taruno, A, Kashio, M, Ohsaki, Y	Sci Rep	2019
29681531	CALHM3 Is Essential for Rapid Ion Channel-Mediated Purinergic Neurotransmission of GPCR-Mediated Tastes Tordoff, MG, Niisato, N, Taruno, A, Foskett, JK, Matsumoto, I, Henao-Mejia, J, Lim, JC, Jyotaki, M, Parker, I, Payne, R, Miyazaki, H, Ohmoto, M, Demuro, A, Ma, Z, Marunaka, Y, Lee, RJ, Hoff, H, Tanis, JE, Mitchell, CH	Neuron	2018
23467090	CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes Adrien, L, Tordoff, MG, Civan, MM, Koppel, J, Chaudhari, N, Abernethy, M, Li, A, Davies, P, Vingtdeux, V, Taruno, A, Foskett, JK, Matsumoto, I, Leung, S, Hellekant, G, Ohmoto, M, Dvoryanchikov, G, Ma, Z, Marambaud, P, Zhao, H	Nature	2013
28202574	Action potentials and ion conductances in wild-type and CALHM1-knockout type II taste cells Saung, WT, Ma, Z, Foskett, JK	J Neurophysiol	2017