Ano1 dimer binds Ca2+

Stable Identifier
Reaction [binding]
Mus musculus
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Ano1 dimer binds Ca2+
Each monomer of the Ano1 dimer (Tmem16a dimer) can bind up to 2 calcium ions at locations in transmembrane helix 6-8 (Dang et al. 2017, Paulino et al. 2017). The first intracellular loop also plays a role in the calcium sensitivity of Ano1 but the mechanism is unknown as this site does not appear to strongly bind calcium (Xiao et al. 2011, Tak et al. 2019).
Literature References
PubMed ID Title Journal Year
29236684 Cryo-EM structures of the TMEM16A calcium-activated chloride channel

Tien, J, Peters, CJ, Chen, T, Jan, YN, Dang, S, Minor, DL, Bulkley, D, Jan, LY, Lolicato, M, Zuberbühler, K, Zhao, J, Cheng, Y, Feng, S, Ye, W, Craik, CS, Qi, L

Nature 2017
29236691 Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM

Kalienkova, V, Neldner, Y, Lam, AKM, Paulino, C, Dutzler, R

Nature 2017
31902154 EF-hand like Region in the N-terminus of Anoctamin 1 Modulates Channel Activity by Ca2+ and Voltage

Oh, U, Yang, YD, Jang, Y, Son, WS, Tak, MH

Exp Neurobiol 2019
21555582 Voltage- and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loop

Xiao, Q, Hartzell, HC, Cui, Y, Arreola, J, Yu, K, Pérez-Cornejo, P

Proc Natl Acad Sci U S A 2011
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