Reactome | Socs1,3:p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 is endocytosed

Socs1,3:p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 is endocytosed

Stable Identifier

R-MMU-9707979

Type

Reaction [omitted]

Species

Mus musculus

Compartment

plasma membrane, endocytic vesicle membrane

ReviewStatus

5/5

General

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Socs1,3:p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 is endocytosed

Binding of Csf3 to Csf3r results in the endocytosis of the Csf3:Csf3r complex (Hermans et al. 1999). Endocytosis depends on a dileucine motif in the C-terminal region of Csf3r.

Literature References

PubMed ID	Title	Journal	Year
9989983	Sustained receptor activation and hyperproliferation in response to granulocyte colony-stimulating factor (G-CSF) in mice with a severe congenital neutropenia/acute myeloid leukemia-derived mutation in the G-CSF receptor gene Ward, AC, Touw, IP, Mayen, AE, Hermans, MH, Ploemacher, RE, Antonissen, C	J Exp Med	1999