p-Y-Stat1,3,5 dimer enhances expression of Socs3

Stable Identifier
R-MMU-9705464
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
p-Y-Stat1,3,5 dimer enhances expression of Socs3

Stat1 dimers (Saito et al. 2000, Gatto et al. 2004), Stat3 dimers (Auernhammer et al. 1999, Kamezaki et al. 2005, Hou et al. 2008), and Stat5 dimers (Emanuelli et al. 2000) bound to the promoter of the Socs3 gene activate transcription of Socs3.

Literature References
PubMed ID Title Journal Year
10820262 IFN regulatory factor-1-mediated transcriptional activation of mouse STAT-induced STAT inhibitor-1 gene promoter by IFN-gamma

Saito, H, Morita, Y, Fujimoto, M, Narazaki, M, Naka, T, Kishimoto, T

J Immunol 2000
18782771 The STAT3 NH2-terminal domain stabilizes enhanceosome assembly by interacting with the p300 bromodomain

Hou, T, Ray, S, Lee, C, Brasier, AR

J Biol Chem 2008
14742442 Analysis of SOCS-3 promoter responses to interferon gamma

Gatto, L, Berlato, C, Poli, V, Tininini, S, Kinjyo, I, Yoshimura, A, Cassatella, MA, Bazzoni, F

J. Biol. Chem. 2004
10821852 SOCS-3 is an insulin-induced negative regulator of insulin signaling

Emanuelli, B, Peraldi, P, Filloux, C, Sawka-Verhelle, D, Hilton, D, Van Obberghen, E

J Biol Chem 2000
10359822 Autoregulation of pituitary corticotroph SOCS-3 expression: characterization of the murine SOCS-3 promoter

Auernhammer, CJ, Bousquet, C, Melmed, S

Proc Natl Acad Sci U S A 1999
15671148 Roles of Stat3 and ERK in G-CSF signaling

Kamezaki, K, Shimoda, K, Numata, A, Haro, T, Kakumitsu, H, Yoshie, M, Yamamoto, M, Takeda, K, Matsuda, T, Akira, S, Ogawa, K, Harada, M

Stem Cells 2005
Participants
This event is regulated
Orthologous Events
Authored
Reviewed
Created
Cite Us!