p-Y-Stat1,3,5 dimer enhances expression of Socs1

Stable Identifier
R-MMU-9705455
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
p-Y-Stat1,3,5 dimer enhances expression of Socs1

The Socs1 gene is transcribed to yield mRNA and the mRNA is translated to yield Socs1 protein. Stat1 dimers (Saito et al. 2000, Chan et al. 2014), Stat3 dimers (Naka et al. 1997), or Stat5 dimers (inferred from Stat1 and Stat3) presumed to be bound to the promoter of the Socs1 gene activate transcription of Socs1.

Literature References
PubMed ID Title Journal Year
10820262 IFN regulatory factor-1-mediated transcriptional activation of mouse STAT-induced STAT inhibitor-1 gene promoter by IFN-gamma

Saito, H, Morita, Y, Fujimoto, M, Narazaki, M, Naka, T, Kishimoto, T

J Immunol 2000
24037089 Dysregulated STAT1-SOCS1 control of JAK2 promotes mammary luminal progenitor cell survival and drives ERĪ±(+) tumorigenesis

Chan, SR, Rickert, CG, Vermi, W, Sheehan, KC, Arthur, C, Allen, JA, White, JM, Archambault, J, Lonardi, S, McDevitt, TM, Bhattacharya, D, Lorenzi, MV, Allred, DC, Schreiber, RD

Cell Death Differ 2014
9202127 Structure and function of a new STAT-induced STAT inhibitor

Naka, T, Narazaki, M, Hirata, M, Matsumoto, T, Minamoto, S, Aono, A, Nishimoto, N, Kajita, T, Taga, T, Yoshizaki, K, Akira, S, Kishimoto, T

Nature 1997
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