Sox9 and Nr5a1 (Sf1) bind the Amh gene

Stable Identifier
R-MMU-9692157
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Sox9 and Nr5a1 (Sf1) bind the Amh gene
Sox9, Nr5a1 (SF1), and Gata4 bind the promoter of the Amh gene (Shen et al. 1994, Viger et al. 1998, Li et al. 2014, Rahmoun et al. 2017).
Literature References
PubMed ID Title Journal Year
28472341 In mammalian foetal testes, SOX9 regulates expression of its target genes by binding to genomic regions with conserved signatures

Symon, A, Philip, GK, Chung, J, Clair, P, Boizet-Bonhoure, B, Bardwell, V, Rahmoun, M, Poulat, F, Murphy, M, Bagheri-Fam, S, Lavery, R, Rossitto, M, Laurent-Chaballier, S, Zarkower, D, Pailhoux, E, Bellora, N, Harley, VR, Cammas, F

Nucleic Acids Res. 2017
30759208 In Vivo Ablation of the Conserved GATA-Binding Motif in the Amh Promoter Impairs Amh Expression in the Male Mouse

Grenier Delaney, J, Harvey, LM, Bouchard, MF, Bergeron, F, Viger, RS

Endocrinology 2019
9636081 Transcription factor GATA-4 is expressed in a sexually dimorphic pattern during mouse gonadal development and is a potent activator of the Müllerian inhibiting substance promoter

Trasler, JM, Mertineit, C, Viger, RS, Nemer, M

Development 1998
25088423 The sex-determining factors SRY and SOX9 regulate similar target genes and promote testis cord formation during testicular differentiation

Zheng, M, Lau, YF, Li, Y

Cell Rep 2014
8205615 Nuclear receptor steroidogenic factor 1 regulates the müllerian inhibiting substance gene: a link to the sex determination cascade

Moore, CC, Shen, WH, Ikeda, Y, Ingraham, HA, Parker, KL

Cell 1994
Participants
Input
Output
Orthologous Events
SOX9, NR5A1 (SF1), and GATA4 bind the AMH gene (Homo sapiens)
Authored
May, B  (2020-06-15)
Reviewed
Imaimatsu, K  (2020-10-29)
Kanai, Y  (2020-10-29)
Created
May, B  (2020-06-20)
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