Sry and Nr5a1 (Sf1) bind Sox9 gene

Stable Identifier
R-MMU-9690401
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Sry and Nr5a1 (Sf1) bind Sox9 gene

Sry and Nr5a1 (SF1) bind several sites in the TES enhancer upstream of the Sox9 coding region (Zediko and Lovell-Badge 2008, Gonen et al. 2018). Sry also binds the Enh13 enhancer upsteam of TES, with the binding to Enh13 stronger than the binding to TES (Gonen et al. 2018).

Literature References
PubMed ID Title Journal Year
29903884 Sex reversal following deletion of a single distal enhancer of Sox9

Gonen, N, Futtner, CR, Wood, S, Garcia-Moreno, SA, Salamone, IM, Samson, SC, Sekido, R, Poulat, F, Maatouk, DM, Lovell-Badge, R

Science 2018
18454134 Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer

Sekido, R, Lovell-Badge, R

Nature 2008
Participants
Input
Output
Orthologous Events
SRY and NR5A1 (SF1) bind SOX9 gene (Homo sapiens)
Authored
May, B  (2020-05-24)
Reviewed
Kanai, Y  (2020-10-29)
Imaimatsu, K  (2020-10-29)
Created
May, B  (2020-05-31)
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